Spironolactone

Brands containing Spironolactone, food notes, and the most important drug interactions.

BRANDS

Avoid potassium-containing products. Potassium products increase the risk of hyperkalemia.
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Take with or without food. Food increases the bioavailability of spironolactone by approximately 95.4%. It should be taken at a consistent time in regards to food.
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EplerenoneCONTRAINDICATED
The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Spironolactone.
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Potassium citrateCONTRAINDICATED
The risk or severity of hyperkalemia can be increased when Potassium citrate is combined with Spironolactone.
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Potassium chlorideMAJOR
The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Spironolactone.
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AcetaminophenMODERATE
Spironolactone may increase the excretion rate of Acetaminophen which could result in a lower serum level and potentially a reduction in efficacy.
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AldesleukinMODERATE
The risk or severity of adverse effects can be increased when Aldesleukin is combined with Spironolactone.
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AlfuzosinMODERATE
Alfuzosin may increase the hypotensive activities of Spironolactone.
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AlprazolamMODERATE
Spironolactone may increase the excretion rate of Alprazolam which could result in a lower serum level and potentially a reduction in efficacy.
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AmitriptylineMODERATE
Amitriptyline may decrease the antihypertensive activities of Spironolactone.
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AmlodipineMODERATE
The risk or severity of hyperkalemia can be increased when Amlodipine is combined with Spironolactone.
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AmphetamineMODERATE
Amphetamine may decrease the antihypertensive activities of Spironolactone.
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