Vardenafil

Brands containing Vardenafil, food notes, and the most important drug interactions.

BRANDS

Avoid grapefruit products. Vardenafil is metabolized by CYP3A4, and grapefruit products are CYP3A4 inhibitors; therefore, coadministration may increase serum levels of vardenafil and result in increased hypotension. .
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Take with or without food. High-fat meals reduce the Cmax of vardenafil; however, there are no changes in AUC or Tmax.
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NitroglycerinCONTRAINDICATED
The risk or severity of hypotension can be increased when Vardenafil is combined with Nitroglycerin.
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Isosorbide dinitrateCONTRAINDICATED
The risk or severity of hypotension can be increased when Vardenafil is combined with Isosorbide dinitrate.
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Isosorbide mononitrateCONTRAINDICATED
Vardenafil may increase the hypotensive activities of Isosorbide mononitrate.
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RiociguatCONTRAINDICATED
Vardenafil may increase the hypotensive activities of Riociguat.
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DarunavirMAJOR
The serum concentration of Vardenafil can be increased when it is combined with Darunavir.
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EtrasimodMAJOR
The risk or severity of QTc prolongation and torsade de pointes can be increased when Etrasimod is combined with Vardenafil.
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ItraconazoleMAJOR
The serum concentration of Vardenafil can be increased when it is combined with Itraconazole.
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AcetaminophenMODERATE
The metabolism of Vardenafil can be decreased when combined with Acetaminophen.
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AcetazolamideMODERATE
The metabolism of Vardenafil can be decreased when combined with Acetazolamide.
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AcetohexamideMODERATE
The metabolism of Vardenafil can be decreased when combined with Acetohexamide.
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